DOSIS OCTREOTIDE PDF

Sandostatin Injection is available as: sterile 1-mL ampuls in 3 strengths, containing 50, mcg octreotide (as acetate), and sterile 5-mL multi-dose vials in 2. Sep 3, Octreotide Acetate (Sandostatin ®) – Intravenous (IV) Dilution. Octreotide (Sandostatin) is the longer acting synthetic analogue of the naturally In patients with cancer and inoperable bowel obstruction octreotide rapidly.

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Elevated transaminase levels Skin and subcutaneous tissue disorders Common: The biochemical characteristic of these tumours is overproduction of vasoactive intestinal peptide VIP.

A limited number of accidental overdoses of Sandostatin in adults and children have been reported. Patients should be monitored periodically. Dosage information for patients with specific tumors follows. Fertility It is not known whether octreotide has an effect on human fertility.

The effect of octreotide on the state of mild diabetes mellitus which frequently occurs is not marked and, in general, does not result in a reduction of requirements for insulin or oral hypoglycaemic agents. In animals, Octreotide is a more potent inhibitor of GH, glucagon octreptide insulin reliease than somatostatin is, with greater selectivity for GH and glucagon suppression. Because of its inhibitory action on growth hormone, glucagon, and insulin, Sandostatin may affect glucose regulation.

Now you can find the tools you need to help manage your patients, all in one place! The dose can be adjusted according to the responses of Cotreotide and thyroid hormones.

Summary of the safety profile The most frequent adverse reactions reported during octreotide therapy include gastrointestinal disorders, nervous system disorders, hepatobiliary disorders, and metabolism and nutritional disorders.

The management of overdosage is symptomatic. Patients on total parenteral nutrition TPN and octreotide should have periodic monitoring of zinc levels. Ampoule is intended for single use only; it should be opened just prior to administration and any unused portion discarded. Thyroid function should be monitored in patients receiving prolonged treatment with octreotide.

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Oesophageal varices Since, following bleeding episodes from oesophageal varices, there is an increased risk for the development of insulin-dependent diabetes or for changes in insulin requirement in patients with pre-existing diabetes, an appropriate monitoring of blood glucose levels is mandatory. The earliest reduction was reported after 14 days of treatment. It inhibits pathologically increased secretion of growth hormone GH and of peptides and serotonin produced within the GEP endocrine system.

Sign Up Log In Cancel. In animals, octreotide is a more potent inhibitor of GH, glucagon and insulin release disis somatostatin is, with greater selectivity for GH and glucagon suppression. The elimination capacity may be reduced in patients with liver cirrhosis, but not in patients with fatty liver disease. Female patients of childbearing potential should be advised to use adequate contraception if necessary during treatment with octreotide see section 4.

Contains less than 1 mmol 23 mg sodium per dose, i. However, because Sandostatin can affect glucose homeostasis, it is recommended that physiological saline solutions be used rather than dextrose.

Dosing Sandostatin® LAR®

Packs of 5 and 30 vials containing 1 ml of solution for injection. However, diarrhoea, which is also a prominent symptom, may not be adequately alleviated by proton pump inhibitors or H2 receptor blocking agents. However, diarrhoea, which is also a prominent symptom, may not be adequately alleviated by proton pump inhibitors or H2 receptor blocking agents. Hepatobiliary disorders Acute pancreatitis, acute hepatitis without cholestasis, cholestatic hepatitis, cholestasis, jaundice, cholestatic jaundice.

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Dosing & Administration

Sign Up Log In Cancel. The effect of Sandostatin on the state of mild diabetes mellitus which frequently occurs is not marked and, in general, does not result in a reduction of requirements for insulin or oral hypoglycaemic agents. In addition, cholelithiasis induced pancreatitis has been reported for patients on long-term Sandostatin s. The relationship of these events to octreotide acetate is not established because many of these patients have underlying cardiac disease.

Date of revision of the text. Animal studies do not indicate direct or indirect harmful effects with respect to reproductive toxicity see section 5. Any unused medicinal product or waste material should dosjs disposed of in accordance with local requirements.

Although administration of Sandostatin often leads to an immediate reduction in plasma glucagon levels, this decrease is generally not maintained over a prolonged period of administration, despite continued symptomatic improvement. Symptomatic control and reduction of growth hormone GH and IGF-1 plasma levels in patients with acromegaly who are inadequately controlled by surgery or radiotherapy.

Although measured faecal fat excretion may increase, there is no evidence to date that long- term treatment with octreotide has led to nutritional deficiency due to malabsorption. Octreotidw effects in the different tumour types octreotude as follows: Ultrasonic examination of the gallbladder before, and at about 6- to month intervals during Sandostatin therapy is therefore recommended. For patients undergoing pancreatic surgery, the peri- dpsis post-operative administration of Sandostatin reduces the incidence of typical postoperative complications e.