DOXIL PI PDF

PI & CMI Trade Names and Active Ingredients containing doxorubicin. 7 Documents available Doxorubicin Ebewe, PI, Doxorubicin hydrochloride. Doxorubicin. Doxil official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more. Find information on drug affordability programs for DOXIL® (doxorubicin HCl liposome injection). Learn how patients who have been.

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Premature menopause can occur with doxorubicin HCl. It is important for patients to remember that physicians have the ability to prescribe medication for conditions other than those for which the drug has been approved by the FDA.

Need help paying for your DOXIL® (doxorubicin HCl liposome injection) prescription?

I have no coverage View all programs. Our Privacy Policy is located at Doxil. Inform patients that following Doxil administration, a reddish-orange color to the urine and other body fluids may be observed. Your doctor will monitor your heart function. Patients may wish to discuss with their physician the other less common side effects of this drug, some of which may be serious. Independent co-pay assistance foundations have their own rules for eligibility.

TGA eBS – Product and Consumer Medicine Information

The pharmacokinetic parameters for total doxorubicin following a single dose of Doxil infused over 30 minutes are presented in Table 8. It is not known whether Doxil is present in human milk.

The mechanism of action of doxorubicin HCl is thought to be related to its ability to bind DNA and inhibit nucleic acid synthesis. Visit this program site copay lls. Independent co-pay assistance foundations Independent co-pay assistance foundations have their own rules for eligibility.

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Data is described for a cohort of p patients retrospectively identified as having disease progression on prior systemic combination chemotherapy at least two cycles of a regimen containing at least two of three treatments: The primary outcome measure was confirmed response rate based on Southwestern Oncology Group SWOG criteria for patients refractory to both paclitaxel- and a platinum-containing regimen. Visit this program site This information is provided as a resource for you.

Please inform your doctor about your history of allergic reactions to medications or other substances.

Do not rapidly flush the infusion line. Painful erythema, edema, or ulcers, and cannot eat Delay dosing up to 2 weeks or until resolved to Grade 0—1. The median time to progression was Infusion reactions may also occur during administration. Inform your doctor of any history of heart disease, radiation to your chest, or prior anticancer therapy. This may lead to tingling or burning, redness, flaking, bothersome swelling, small blisters, or small sores on palms of hands or soles of feet.

Sperm counts have been reported to return to normal levels in some men. Speak to your doctor if you notice any changes in your health such as a new onset fever or symptoms of infection.

IMPORTANT SAFETY INFORMATION

In females of reproductive potential, Doxil may cause infertility and result in amenorrhea. No, I am not. Please check back, as programs change. Males with female sexual partners of reproductive potential should use effective contraception during and for 6 months after treatment with Doxil [see Non-clinical Toxicology When should patients notify their physician? What is the mechanism of action?

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All occurred during cycle 1 and none during subsequent cycles. We have also listed most of the eligibility requirements for each, so you can narrow your focus to those that best suit your circumstances.

The risk of cardiomyopathy with doxorubicin HCl is generally proportional to the cumulative exposure. Odxil nontoxic reaction is due to the color of the product and will dissipate as the drug is eliminated from the body. What can patients do to help alleviate or prevent discomfort and side effects? Patients should discuss the appropriateness of a particular drug or chemotherapy regimen with their physician.

The relationship between cumulative Doxil dose and the risk of cardiac toxicity has not been determined.

Po hundred forty-five of these patients were refractory to both paclitaxel- and platinum-based chemotherapy regimens, defined as disease progression while on treatment or relapse within 6 months of completing treatment.

Infusion reactions may also occur during administration. This may occur several years after the end of therapy [see Non-clinical Toxicology