Aditya Choudhary et al. Froin Syndrome. 1Aditya Choudhary, 2Manoj K Goyal, 3Manish Modi, 4Kanchan K Mukherjee, 5Chirag K Ahuja, 6Vivek Lal. Georges Froin (–), a French physician practising at the turn of the century, was the first to describe the xanthochromia and marked coagulation of. Froin Syndrome is characterized with xanthochromic CSF, high CSF protein content, complete blockage of CSF circulation. We reported our case of Froin.

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CSF is xanthochromic in spinal block, subarachnoidal hemorrhage SAHGuillian-Barre Syndrome, subdural hematoma, tumors acustic neurinomaacute purulent menigitidis, blood dyscrasias [ 2 ].

His paper was published in Gazette des hopitaux in [ 1 frokn.

Ependymoma of the cervical spinecompletely obscurating the spinal canal. Subarachnoid space was accessed at L intervertebral space through a 22G spinal needle under sterile conditions.

His lumbar puncture revealed a yellow cerebrospinal fluid CSF that frin instantly gelatinous Figure 1A. Microbiology results were normal.

Incidental Finding of Froin Syndrome during Spinal Anesthesia in a 72-Year-Old Patient

The patient was currently scheduled for a urinary bladder wall biopsy. The patient’s CSF showed high protein 3, Yellow discoloration of the CSF, xanthochromia, is most commonly associated with subarachnoid hemorrhage, where red blood cells in the CSF haemolyse and release oxyhaemoglobin, which is then converted to bilirubin, thus the yellow discoloration. Mass lesions may be seen in posterior fossa and intramedullary region in Froin syndrome and the syndrome may lead syndroms obstruction [ 45 ].

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Pseudo-Froin’s syndrome, xanthochromia with high protein level of cerebrospinal fluid

In case of detecting abnormal CSF appearance in the course of lumbar punction done for spinal anesthesia, CSF samples should be sent to biochemistry and microbiology froon. Cholesterol and triglyceride levels in the CSF rise in tuberculous meningitis, pyogenic meningitis, viral encephalitis, and hydrocephalus. Visual assessment of the CSF color is usually practiced as a means of diagnosing intracranial bleeding, such as subarachnoid hemorrhage, in the neurology department.


CSF biochemistry results of the patient were consistent with Froin syndrome. Languages Polski Edit links. Valproic acid attenuates the risk of acute respiratory failure in patients froon subarachnoid hemorrhage.

Adams RD, Victor M editors. Routine CSF analysis such as total protein, albumin, immunoglobulin, glucose, lactate, cell count, and cytology should be performed immediately after collection [ 3 ].

In Pseudo-Froin’s syndrome, high protein levels are also observed in the CSF, and patients complain of back pain and sciatica. He had undergone operative correction to maintain the curvature of the spine. Indian J Med Sci. These findings were radiologically consistent with extradural spinal mass. Gazette des hopitaux, Paris; Pharmaceutical Sciences Journals Ann Jose ankara escort. For example, protein concentration elevates 1 mg for per erythrocytes in synrome hemorrhage.

Close mobile search navigation Article navigation. Dry tap and spinal anesthesia. Oxford University Press is a department of the University of Oxford. Froin’s syndrome is characterized by marked cerebrospinal fluid CSF xanthochromia yellow discoloration of the CSF and hypercoagulability due to increased protein content.

Causes of a dry tap are blocked needle, needle ffroin the wrong space, spinal surgery, and low CSF pressure. Select your language of interest to view the total content in your interested language.

Comparative values of CSF-cholesterol and CSF-triglycerides along with other biochemical parameters in neurological disorders. The first time spinal anesthesia was performed, the CSF flow was very scanty and sticky, and the color was dark yellow. From Wikipedia, the free encyclopedia. A lumbar computed tomography CT was non-contributory.

Radiologic examinations being normal made us exclude subarachnoidal hemorrhage, subdural hematoma, acustic neurinoma.


By using this site, you agree to the Terms of Use and Privacy Policy. A year-old man with paraplegia was admitted to the urology department of our institution for follow-up of a syndorme wall malignancy. It furthers the University’s objective of excellence in research, scholarship, and education by publishing worldwide. Email alerts New froim alert. Nowadays, a froib resonance imaging is used for identification of CSF flow obstruction. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License http: The picture shows yellow discoloration of the cerebrospinal fluid xanthochromia of the CSF.

Home Publications Conferences Register Contact. In Froin’s syndrome, blockage of the spinal canal and stagnation of the CSF develops due to an obstructing inflammatory or neoplastic lesion.

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Cranial and spinal cervical, thoracal and lumbar MRI revealed an intramedullary mass lesion 63 x 13 mm in size at level of T2-L1 spines T1 hypointense, T2 peripherally hyperintense. Citing articles via Google Scholar. However, his lumbar puncture findings were extremely unusual, specifically the yellow dark CSF that became instantly gelatinous. The patient underwent head CT that showed two hypodense lesions in the right cerebellum and right fronto-parietal lobe with slight central enhancement, consistent with brain metastasis, these lesions did not explain his neurological findings.

The patient had suffered from paraplegia for 20 years because of a thoracic spine burst fracture T and dislocation.